DescriptionMass spectrometry has become the dominant tool throughout the drug discovery / development continuum. This short course will offers an overview of mass spectrometry in drug target identification, drug metabolism and pharmacokinetics (DMPK) in support of drug discovery. The course will focus on “why” and “how” knowledge base with regard to the use of mass spectrometry in drug discovery. Contents will include an introduction to concepts and principles of DMPK and an overview of drug discovery and development process. Current mass spectrometry technologies applied in ADME screening in lead optimization, drug quantification in PK studies, drug metabolite identification in animals and humans. Practical examples will provide the opportunity to discuss these and other opportunities in drug discovery.;;Major Course Topics;;• How mass spectrometers work (Ion Trap, Quadroupole, Time-Of-Flight & Orbitrap).;;• Ionization approaches for biological and chemical analysis.;;• Overview of drug discovery and development in pharmaceutical industry.;;• Basic DMPK concepts applied in pharmaceutical research and their role in drug discovery.;;• ADME screening and characterization in lead optimization.;;• Drug metabolite profiling and identification in drug discovery.;;• Quantitative analysis of drug candidates and their metabolites in animals and humans by LC-MS.;;• Automation and high throughput applications of mass spectrometry .;;• New MS technologies.;
Ma’an Amad is a Senior Research Scientist and the head of the Chromatographic Separation/Mass spectrometry Laboratory at KAUST Analytical Chemistry Core Laboratory. Prior to that, he worked at Boehringer Ingelheim R&D center, Canada, as senior research scientist in the drug discovery group. He has over 10 years experience in the field of analytical chemistry and drug discovery, with a primay focus on mass spectrometry. He received his doctorate in analytical chemistry from Iowa State University in 1999, where his research focused on developing of a protocol high resolution quadrupole mass analyzer to solve the problem of ion interferences in mass spectrometry. He then undertook a post doctoral research position at the University of New Mexico, where was involved in the verification and characterization of Electrospray ionization operating modes. As a senior research scientist at Boehringer Ingelheim R&D center, Canada, he was responsible in the creation and buildup of a drug discovery mass spectrometry group within the Department of biological science. In addition he was acting as a Drug Discovery Project Manager with the responsibility of managing the Drug Metabolism support of major potential new drugs to treat Hepatitis C (HCV) and Human Immunodeficiency Virus (HIV) resulting in two recommended compounds being progressed to development. Author of more than 35 journal and conference papers, Dr. Amad’s research interests are focused in the area of bioanalytical and environmental chemistry. In the area of bioanalytical chemistry and drug discovery, the main objectives of his research are to develop advanced methods and strategies for the detection and characterization of biomarkers and metabolites in biological systems. As for the environmental chemistry, his research interests involve the development and application of innovative analytical techniques to study the presence fate and effects of pesticides, pharmaceuticals, veterinary medicines, and personal care products in the environment.
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