DescriptionSuccessful recognition of foreign antigens by antibodies (or immunoglobulins) is crucial for the defense of an organism against pathogens and strictly depends upon the enormous diversity of the sequences and structures of these molecules. At the same time these molecules play an exceptionally important role in diagnosis, therapy and biotechnology applications.;;The course will discuss the sequence and structure of antibodies showing the relationship between the various elements of these modular proteins and their function and the available methods for predicting their structure.;;It will also discuss how the knowledge of the sequence-structure relationship in this class of molecules can be effectively used for medical (diagnosis and humanization) and biotechnological (library design and re-engineering) applications.
Anna Tramontano, a KAUST Investigator, was trained as a physicist but she soon became fascinated by the complexity of biology and by the promises of computational biology. After a post-doctoral period at UCSF, she joined the Biocomputing Programme of the EMBL in Heidelberg. In 1990 she moved back to Italy to work in the Merck Research Laboratories near Rome. In 2001, she returned to the academic world as a Chair Professor of Biochemistry in "La Sapienza" University in Rome where she continues to pursue her scientific interests on protein structure prediction and analysis in the Department of Biochemical Sciences. She is a member of the European Research Council, of the European Molecular Biology Organization and of the organizing Committee of the Critical Assessment of Techniques for Protein Structure Prediction (CASP) initiative.She is also a member of the Advisory Board of several Institutions (EMBL, EBI, Max Planck, CRG, etc.) and Associate Editor of Bioinformatics, Proteins and PlOS One. She has published about 200 papers in peer reviewed journals and four books.
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