Most pathogens including bacteria, fungi, viruses and protozoa carry unique glycans on their surface. Currently, several vaccines against bacteria are marketed very successfully. Since many pathogens cannot be cultured and the isolation of pure oligosaccharides is extremely difficult, synthetic oligosaccharide antigens provide now a viable alternative. Based on the automated synthesis platform, and commercialized. The quality control of synthetic oligosaccharides by ion mobility mass spectrometry (IM-MS) is fast and extremely sensitive. In addition to their function as antigens, synthetic oligosaccharides serve as tools to create monoclonal antibodies, and to establish glycan microarrays to map vaccine epitopes. Diagnostic and preventive approaches against a host of bacteria, fungi, and parasites are being pursued.
In recent years continuous flow systems have become increasingly interesting to practitioners of synthetic chemistry. Described is the use of continuous flow systems to produce drug substances and other chemicals via multi step reactions including continuous purification. The anti-malaria drug artemisinin and its derivatives as well as other life-saving drugs are used as examples.
Peter H. Seeberger studied chemistry in Erlangen (Germany) and completed a PhD in biochemistry in Boulder (USA). After performing research at the Sloan-Kettering Cancer Center Research in New York he built an independent research program at MIT where he was promoted to Firmenich Associate Professor of Chemistry with tenure. After six years as Professor at the Swiss Federal Institute of Technology (ETH) Zurich he assumed positions as Director at the Max-Planck Institute in Potsdam and Professorships at the Free University of Berlin and at the University of Potsdam.
Professor Seeberger’s research has been documented in over 440 peer-reviewed journal articles, four books, more than 35 patents, and more than 800 invited lectures. This work was recognized with more than 25 international awards. He greatly supports the idea of open access publishing as the Editor-in-Chief of the Beilstein Journal of Organic Chemistry and serves on the editorial advisory boards of many other journals.
Peter Seeberger is a co-founder of the Tesfa-Ilg “Hope for Africa” Foundation. The research in the Seeberger laboratory has given rise to several companies in the USA and Germany.
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